Joint Regeneration Therapy is an intra-articular injection treatment aimed at modifying the underlying pathophysiology of osteoarthritis (OA), rather than simply masking its symptoms. By combining Sildenafil Citrate, Mepivacaine HCL and Glucose, this treatment works to restore basic cellular parameters within the joint back to a normal physiological state.
At a cellular level, the therapy supports intracellular Ca2+ signalling, increases Na+/K+-ATPase activity, enhances glucose uptake and downregulates TLR4 within cartilage and bone cells. In doing so, it helps to alleviate the expression of inflammatory mediators associated with the structural damage seen in cartilage and subchondral bone, supporting a healthier joint environment and improved comfort for the horse.
Frequently asked questions
This intra-articular injection combines Sildenafil Citrate, Mepivacaine HCL and Glucose to target the underlying pathophysiology of osteoarthritis, rather than simply relieving pain. The treatment aims to restore basic cellular parameters within the joint back to a normal physiological state.
This includes supporting intracellular Ca2+ signalling, increasing Na+/K+-ATPase activity and enhancing glucose uptake within joint tissue. Together these effects downregulate TLR4, helping cartilage and bone cells reduce the inflammatory mediators associated with structural damage in cartilage and subchondral bone.
Joint Regeneration Therapy is primarily used in horses affected by osteoarthritis (OA), where it can help support joint health and comfort by addressing the cellular changes that drive ongoing inflammation and structural damage within the joint.
The treatment is given as an intra-articular injection directly into the affected joint. As with our other services, this can be carried out at your property as part of our mobile veterinary care.